Triple-negative breast cancer (TNBC) is \nchallenging, making up 15\u201320% of all breast cancer cases. This study \nexamined how certain drugs, like lapatinib (a dual tyrosine kinase \ninhibitor targeting EGFR and Her2) and berberine (a plant-based \ncompound), affect TNBC cells. We found that lapatinib activates a \nprotein called Akt in MDA-MB231 TNBC cells, which could contribute to \nthe cancer\u2019s resistance to treatment. We also studied the genetic \nprofiles of different TNBC cell lines and patients. Interestingly, \nlapatinib and berberine enhanced Akt activity in TNBC cells, making them\n more resistant to treatment. These findings suggest that these drugs \nmay not be effective in treating TNBC and could even make the cancer \nmore resistant to therapy.<\/p>

<\/p><\/div><\/div>\n

Our\n recent research analyzed the gene expression of specific \ncancer-promoting proteins in ten different triple-negative breast cancer\n (TNBC) cell lines and TNBC patients, utilizing GEO and TCGA databases. \nOur current findings have highlighted that the majority of the chosen \ncell lines, including MDA-MB231 and TNBC patients, exhibit decreased \nlevels of AKT1, PIK3CA, PTEN, and EGFR genes while showing increased \nlevels of KRAS and DNMTs. These observations suggest that these genes \nare associated with the invasive nature of TNBC.<\/p><\/div><\/div>

<\/p>\n\n\n\n\n\n\n\n\n

\ud83d\udd2c Calling All Young Researchers in Cancer\n Research! Join the Targeted-Therapy Subgroups and Shape the Future of \nSolid Tumor Treatment! \ud83c\udf1f<\/h3>
\n<\/p>\n\n\n
Are you a passionate young researcher with a burning desire to make a difference in the world of cancer research? \ud83e\uddb8\u200d\u2642\ufe0f\ud83e\uddb8\u200d\u2640\ufe0f<\/p>\n
At the Cancer Discovery Network, we\u2019re on a mission to unlock the full potential of targeted therapy against solid tumors, with a special focus on breast cancer. \ud83d\udcaa\ud83e\ude7a<\/p>\n
We believe that collaboration and innovation are the keys to breakthroughs, and that\u2019s where you come in! We\u2019re excited to introduce our new initiative: the Targeted-Therapy Subgroups. \ud83c\udfaf<\/p>\n
Here\u2019s how you can get involved: <\/p>\n
1\ufe0f\u20e3 Collaborate:<\/strong> Join a diverse and dynamic community of researchers dedicated to advancing targeted therapy. <\/p>\n
2\ufe0f\u20e3 Ideate:<\/strong> Share your innovative ideas, and let\u2019s brainstorm the next generation of treatment strategies. <\/p>\n
3\ufe0f\u20e3 Research:<\/strong> Dive deep into the world of solid tumors, especially breast cancer, and explore novel approaches. <\/p>\n
4\ufe0f\u20e3 Network:<\/strong> Connect with like-minded individuals, mentors, and experts in the field. <\/p>\n
5\ufe0f\u20e3 Impact:<\/strong> Be part of groundbreaking research that has the potential to transform cancer treatment.<\/p>\n
We\u2019re looking for enthusiastic individuals who are ready to roll up their sleeves and tackle the challenges of cancer head-on. Whether you\u2019re a seasoned researcher or just starting your journey, your unique perspective and ideas are invaluable. \ud83e\uddec\ud83d\udd0d<\/p>\n
Join us in the fight against cancer, and let\u2019s work together to bring hope, healing, and innovation to patients worldwide. \ud83d\udc97<\/p>\n
Interested? Reach out to us today, and let\u2019s embark on this exciting journey of discovery and progress. \ud83d\ude80<\/p>\n\n\n\n\n\n\n\n\n\n

c-MET Discovery Subgroup<\/h3>
<\/h2>\n\n\n\n
The\n c-MET Discovery Subgroup focuses on studying a protein called c-MET, \nwhich is super important in cancer. They want to understand how c-MET \naffects how cancer cells resist treatments like targeted therapies and \nimmunotherapies. They\u2019ve found that c-MET plays a big role in making the\n tumor environment friendly to cancer cells by helping them hide from \nthe immune system.<\/p>
Their\n research shows that when c-MET is too active, it\u2019s linked to a protein \ncalled PD-L1, which cancer cells use to protect themselves from the \nimmune system. Also, c-MET seems to change some immune cells from \nfighting cancer to supporting it, and it helps create more immune cells \nthat suppress the immune response in the tumor.<\/p>
<\/p>
<\/p>\n
The\n subgroup is exploring exciting possibilities. They\u2019ve been looking at a\n special antibody called amivantamab, which can target two things: c-MET\n and EGFR. This antibody seems to help the immune system fight cancer \nbetter. This discovery opens doors to new treatments that use both c-MET\n blocking and immunotherapy, like a double attack against cancer growth \nand immune suppression.<\/p>
All\n in all, this subgroup\u2019s research is crucial. It helps us understand how\n c-MET works in cancer, giving hope for better treatments tailored to \neach patient. Their dedication to uncovering the mysteries of c-MET in \ncancer is vital for finding new ways to fight this disease.<\/p><\/div><\/div><\/div>
<\/p>\n\n\n\n\n\n
Plant-based Drug Discovery Subgroup<\/span>
<\/h2>\n\n
\ud83c\udf3f Unlocking the Power of Nature in the Fight Against Cancer<\/strong> \ud83c\udf3f<\/h3>\n
Are you passionate about exploring the untapped potential of plant-based anticancer drugs? \ud83c\udf31 Do you believe in the healing properties of nature\u2019s pharmacy? \ud83c\udf3c Join our Natural-Based Anticancer Pharmacology Subgroup and be part of a groundbreaking journey!<\/p>
Why Plant-Based Anticancer Drugs Matter:<\/strong><\/p>
Nature has provided us with a treasure trove of compounds that have shown remarkable anticancer properties.<\/li>
Plant-based drugs offer a promising avenue for developing effective and less toxic cancer treatments.<\/li>
Research in this field has the potential to revolutionize cancer therapy and improve patient outcomes.<\/p><\/li><\/span>
<\/p><\/li><\/ul>
What We Do:<\/strong><\/p>
Explore the vast world of natural compounds and their anticancer potential.<\/li>
Investigate the mechanisms of action behind these plant-based drugs.<\/li>
Collaborate with experts, researchers, and students who share a passion for natural-based anticancer pharmacology.<\/li>
Contribute to the development of safer and more accessible cancer treatments.<\/li><\/ul><\/span>
Why Join Us:<\/strong><\/p>
Gain valuable insights and expertise in the field of natural-based anticancer pharmacology.<\/li>
Collaborate on exciting research projects with real-world applications.<\/li>
Connect with a vibrant community of like-minded individuals dedicated to advancing cancer research.<\/li>
Make a meaningful impact on the future of cancer treatment and drug development.<\/li><\/ul>
Let\u2019s Harness the Healing Power of Nature Together! \ud83c\udf3f<\/strong>\n<\/p><\/span><\/span>\n
Join us in our mission to unlock the full potential of plant-based anticancer drugs. Together, we can make a difference in the lives of cancer patients and bring hope for a healthier future. \ud83c\udf1f<\/p>
Ready to be a part of this transformative journey? Click the \u201cJoin Us\u201d button and become a member of our Natural-Based Anticancer Pharmacology Subgroup today! \ud83c\udf3c\ud83d\udd2c\ud83e\uddea<\/p><\/span><\/span>\n\n\n\n\n\n\n\n<\/body>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"pagelayer_contact_templates":[],"_pagelayer_content":"","footnotes":""},"class_list":["post-547","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/cancerdiscovery.net\/open\/wp-json\/wp\/v2\/pages\/547","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cancerdiscovery.net\/open\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cancerdiscovery.net\/open\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cancerdiscovery.net\/open\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cancerdiscovery.net\/open\/wp-json\/wp\/v2\/comments?post=547"}],"version-history":[{"count":5,"href":"https:\/\/cancerdiscovery.net\/open\/wp-json\/wp\/v2\/pages\/547\/revisions"}],"predecessor-version":[{"id":865,"href":"https:\/\/cancerdiscovery.net\/open\/wp-json\/wp\/v2\/pages\/547\/revisions\/865"}],"wp:attachment":[{"href":"https:\/\/cancerdiscovery.net\/open\/wp-json\/wp\/v2\/media?parent=547"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

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\ud83d\udce2 Important Update: Submit Your Manuscript on RTK signaling!
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